Paclitaxel-coated drug-eluting balloon for pulmonary vein stenosis after repair of total anomalous pulmonary venous return with asplenia

Hiroshi Ono, Ryo Mafune, Taiyu Hayashi, Yasushi Misaki, Yukihiro Kaneko, Jumpei Saito, Miki Nagai, Hitoshi Kato

National Medical Center for Child Health and Development.
Japan

Journal of Cardiology Cases
J Cardiol Cases 2020; 22: 107-109
DOI: 10.1016/j.jccase.2020.05.008

Abstract
We used a paclitaxel-coated drug-eluting balloon (DEB) for pulmonary vein stenosis (PVS) after repair of total anomalous pulmonary venous return with asplenia. No adverse effect of paclitaxel was revealed and plasma concentration of paclitaxel was not elevated after intervention. Although progression of PVS slowed after dilatation with the DEB, stenosis recurred relentlessly, resulting in patient demise. This strategy may be safe for infantile cases, but requires further effective strategy, such as usage of larger sizes of DEBs.
Learning objective: Paclitaxel-coated drug-eluting balloons may be safely used for pulmonary vein stenosis after total anomalous pulmonary venous return repair in an infant with asplenia. However, their effectiveness is still limited.

Category
Stenosis or Obstruction of Pulmonary Veins Following Surgical Repair of Anomalous Pulmonary Venous Connections
Catheter-mediated Interventions: Efficacy or Lack of Efficacy
Medical Therapy to Prevent Recurrence of Disease after an Intervention. Efficacy or Lack of Efficacy

Year of Publication: 2020

Age Focus: Pediatric

Article Type: Case Reports or Retrospective Observations in Small Groups of Patients (≤10 patients)

Article Access: Free PDF File or Full Text Article Available Through PubMed or DOI: Yes