Usha S. Krishnan, Mary P. Mullen
Vagelos College of Physicians and Surgeons of Columbia University Irving Medical Center and Morgan Stanley Children’s Hospital of New York Presbyterian. Boston Children’s Hospital and Harvard Medical School.
United States
Comprehensive Physiology Interorgan Communication in Health and Disease
Compre Physiol 2025;
DOI: 10.1002/cph4.70085
Abstract
Understanding communication between various organ systems is vital to understanding the pathophysiology of disease, and this assists in tailoring appropriate therapies. Pulmonary vein stenosis is an example of a multi-organ disease process that occurs in infancy and later throughout life. The organs involved may be at a distance from the heart and lungs or from within the thoracic cavity. In former preterm infants with bronchopulmonary dysplasia (BPD), this condition is associated with ongoing inflammation in other organ systems, including lung parenchyma as well as the gut. It is also associated with perturbation in blood flow due to intracardiac shunt lesions or external pressure from intrathoracic structures. In patients with congenital heart disease (CHD) associated with PVS at baseline or after surgery involving pulmonary veins, there may be a genetic component to the development of PVS as well as factors like flow and shear stress and other less understood instigators of tissue proliferation within the veins. Understanding these interactions has led to improved surveillance as well as the development of protocols for the evaluation of pulmonary veins in the setting of infection or inflammation of the other organs and in patients otherwise predisposed to developing PVS. This early surveillance has resulted in prompt diagnosis, targeted drug development tailored to the disease process, appropriate and timely intervention with improved outcomes.
Category
Stenosis or Obstruction of Normal Pulmonary Venous Connections
Incidence or Prevalence of Disease
Genetic Factors Influencing the Onset, Severity or Outcome of Disease
Patient Factors Influencing the Onset, Severity or Outcome of Disease
Environmental Factors Influencing the Onset, Severity or Outcome of Disease
Year of Publication: 2025
Age Focus: Pediatric
Article Type: Review
Article Access: Free PDF File or Full Text Article Available Through PubMed or DOI: No