Martin Hosking, Mary Redmond, Lila Allen, Lother Broecker, Marilyn Keaney, Julie Lebeau, Virginia Walley
Children’s Hospital of Eastern Ontario.
Canada
Catheterization and Cardiovascular Diagnosis
Catheter Cardiovasc Diagn 1995; 36: 90-96
DOI: 10.1002/ccd.1810360123
Abstract
The outcome of stent implantation for children with pulmonary venous obstruction has been characterized by late reocclusion associated with a marked vessel neointimal proliferation. The purpose of this study was to compare the responses of the systemic vein and pulmonary vein to the presence of an intravascular stent, using a Yorkshire swine (N = 10) model. Under cardiopulmonary bypass, a single Palmaz stent was placed in the inferior vena cava (IVC) and right lower pulmonary vein (PV) with sacrifice at 4.9-6.1 months. Angiography and hemodynamic data were determined at 1 and 3 months post-stent implant and prior to euthanasia. All stents were found to be patent, with no difference in degree of thrombosis or neointimal formation. No statistical difference was found in the initial and final stent diameter for both inferior vena cava and pulmonary vein stents (PV initial 6.8 +/- 0.9; final 7.1 +/- 0.6) (IVC initial 10.4 +/- 1.2; final 10.4 +/- 1.2). Electron microscopy demonstrated smooth endothelialization of both pulmonary and systemic venous stent devices. No thrombosis was found on gross morphology. The data indicate that there is no intrinsic difference in the response of the pulmonary vein to the presence of a stent device. The clinical experience of restenosis following stent implantation for pulmonary vein stenosis appears to be more related to variables of final stent diameter combined with the marked intrinsic abnormal vessel architecture, as seen with this condition.
Category
Catheter-mediated Interventions: Efficacy or Lack of Efficacy
Pulmonary Venous Pathology
Year of Publication: 1995
Age Focus: None
Article Type: Animal Models of Disease and Therapy
Article Access: Free PDF File or Full Text Article Available Through PubMed or DOI: No