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An Integrated Lumped Parameter Model and Computational Fluid Dynamics Framework for Predicting Hemodynamic Parameters in Pulmonary Vein Stenosis

Alessia Di Nardo, David A. Romero, Rachel D. Vanderlaan, Cristina H. Amon University of Toronto and Hospital for Sick Children.Canada Comprehensive PhysiologyCompr Physiol 2026; 16: DOI: 10.1002/cph4.70185 AbstractPediatric pulmonary vein stenosis (PVS) is a progressive vascular disease associated with poor long-term outcomes. A growing body of evidence supports a relationship between the mechanisms of PVS pathogenesis […]

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Case Report: Post-Total anomalous pulmonary venous connection pulmonary hypertension – novel treatment using sirolimus and atrial flow regulator implantation

Stasa Krasic, Antony Hermuzi, Ivan Dizdarevic, Vesna Topic, Nevena Djorovic, Mihail Basa, Vladislav Vukomanovic Mother and Child Health Institute of Serbia and University of Belgrade. Freeman Hospital and Newcastle upon Tyne Hospitals NHS Foundation Trust.Serbia and United Kingdom Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2026; 13:DOI: 10.3389/fcvm.2026.1783773 AbstractObjective: In patients who have undergone surgical repair of TAPVC

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Therapeutic Targets for Pediatric Pulmonary Vein Stenosis: Insights from Animal Models

Siqi She, Debao Li, Qi Sun, Lincai Ye Shanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Children’s Hospital of Fudan University and National Children’s Medical Center.China ChildrenChildren 2026; 13:DOI: 10.3390/children13050677 AbstractPulmonary vein stenosis (PVS) is a rare and devastating condition affecting infants and children, characterized by progressive intimal hyperplasia, myofibroblast proliferation, and

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Losartan attenuates upstream vasculopathy in a modified piglet model of pulmonary vein stenosis: contribution of the Hippo pathway

Wenhui Zeng, Siming Liu, Zhen Xu, Fangbao Ding, Ju Mei, Jiaquan Zhu Xinhua Hospital, Shanghai Jiaotong University School of Medicine.China Annals of Translational MedicineAnn Transl Med 2022; DOI: 10.21037/atm-22-2621 AbstractBackground: Diffuse pulmonary vein stenosis (PVS) is an intractable congenital heart disease for which the underlying mechanism remains unclear. In this study, we investigated the effect of losartan

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Swine model of chronic postcapillary pulmonary hypertension with right ventricular remodeling: long-term characterization by cardiac catheterization, magnetic resonance, and pathology

Daniel Pereda, Ana Garcia-Alvarez, Damián Sánchez-Quintana, Mario Nuño, Leticia Fernández-Friera, Rodrigo Fernández-Jiménez, José Manuel García Ruíz, Elena Sandoval, Jaume Aguero, Manuel Castellá. Roger J. Hajjar, Valentín Fuster, Borja Ibáñez Centro Nacional de Investigaciones Cardiovasculares Carlos III.Spain Journal of Cardiovascular Translational ResearchJ Cardiovasc Transl Res 2014; 7: 494-506DOI: 10.1007/s12265-014-9564-6 AbstractPulmonary hypertension (PH) is prevalent and carries high

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Dynamic behavior and lineage plasticity of the pulmonary venous endothelium

Joanna Wong, Gan Zhao, Stephanie Adams-Tzivelekidis, Hongbo Wen, Prashant Chandrasekaran, Sylvia N. Michki, Maria E. Gentile, Madeline Singh, Sara Kass-Gergi, Meryl Mendoza, Nicolas P. Holcomb, Xinyuan Li, Alan T. Tang, Nicholas M. Negretti, Jennifer M. S. Sucre, David B. Frank, Andrew E. Vaughan University of Pennsylvania and Children’s Hospital of Philadelphia. Vanderbilt University Medical Center.

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Transcatheter Interventional Options in Pulmonary Vein Stenosis: When to Stent?

Heidi Van Christopher J. Petit, Oliver M. Barry Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian Hospital Morgan Stanley Children’s HospitalUnited States Seminars in Thoracic and Cardiovascular Surgery Pediatric Cardiac Surgery AnnualSemin Thorac Cardiovasc Surg Pediatr Card Surg Ann 2026;DOI: 10.1053/j.pcsu.2026.02.007 AbstractPulmonary vein stenosis (PVS) is a rare and aggressive condition in infants and

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Pulmonary Vein Stenosis Medical Therapy: Current and on the Horizon

Mudit Gupta, David B. Frank Perelman School of Medicine at the University of Pennsylvania and Children’s Hospital of PhiladelphiaUnited States Seminars in Thoracic and Cardiovascular Surgery Pediatric Cardiac Surgery AnnualSemin Thorac Cardiovasc Surg Pediatr Card Surg Ann 2026;DOI: 10.1053/j.pcsu.2026.02.006 AbstractPulmonary vein stenosis (PVS) is a severe vascular obstructive lesion historically associated with poor survival. As outcomes

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Pathogenesis, Evaluation, and Management of Pulmonary Vein Stenosis: JACC Review Topic of the Week

Trevor Simard, Dhruv Sarma, William R. Miranda, Charles Jain, Jason H. Anderson, Jeremy D. Collins, Abdallah El Sabbagh, Aravdeep Jhand, Tobias Peikert, Guy S. Reeder, Thomas M. Munger, Douglas L. Packer, David R. Holmes Mayo Clinic.United States Journal of the American College of CardiologyJ Am Coll Cardiol 2023; 81: 2361-2373DOI: 10.1016/j.jacc.2023.04.016 AbstractPulmonary vein stenosis (PVS) can

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Pulmonary arterial hypertension caused by compression of the left lower pulmonary vein in children

Li Chen, Cheng Wang, Jiachen Li, Lizhi Lv, Yongtao Wu, Gang Li, Guofeng Xing, Xiaoyong Jing, Zhimin Liu, Qiang Wang Beijing Anzhen Hospital and Capital Medical University.  Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.China Journal of Cardiothoracic SurgeryJ Cardiothorac Surg 2026;DOI: 10.1186/s13019-026-04085-x AbstractObjectives To investigate, through

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