Article Type: Animal Models of Disease and Therapy

Progression of vascular remodeling in pulmonary vein obstruction

Naoki Masaki, Osamu Adachi, Shintaro Katahira, Yuriko Saiki, Akira Horii, Shunsuke Kawamoto, Yoshikatsu Saiki Tohoku University Graduate School of Medicine.Japan Journal of Thoracic and Cardiovascular SurgeryJ Thorac Cardiovasc Surg 2020; 160: 777-790.e5DOI: 10.1016/j.jtcvs.2020.01.098 AbstractObjectives: Pulmonary vein obstruction (PVO) frequently occurs after repair of total anomalous pulmonary vein connection with progression of intimal hyperplasia from the anastomotic site […]

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Alterations in elastin and collagen related to the mechanism of progressive pulmonary venous obstruction in a piglet model. A hemodynamic, ultrastructural, and biochemical study

Jay I. LaBourene, John G. Coles, Dorothy J. Johnson, Arun Mehra, Fred W. Keeley, Marlene Rabinovitch Hospital for Sick Children.Canada Circulation ResearchCirc Res 1990; 66: 438-456DOI: 10.1161/01.res.66.2.438 AbstractWe created an animal model to understand better the pathogenesis and underlying mechanism of progressive central pulmonary venous (PV) obstruction, a condition not amenable to current therapy. Twenty piglets

Alterations in elastin and collagen related to the mechanism of progressive pulmonary venous obstruction in a piglet model. A hemodynamic, ultrastructural, and biochemical study Read More »

Technical problems in lung allotransplantation. Causes of pulmonary venous outflow obstruction

Gary H. Stevens, Decio M. Rangel, Yozo Yakeishi, Eric W. Fonkalsrud UCLA School of Medicine.United States Archives of SurgeryArch Surg 1969; 99: 506-512DOI: 10.1001/archsurg.1969.01340160086020 AbstractExperience in this laboratory with approximately 100 canine and primate lung allotransplantation operations over the past 18 months has made clear the fact that technical problems are the cause of a large

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