Medical Therapy. Adverse Effects or Lack of Adverse Effects

A prospective phase II trial of vinblastine and methotrexate in multivessel intraluminal pulmonary vein stenosis in infants and children

Maliha Rehman, Kathy J. Jenkins, Amy L. Juraszek, Jean A. Connor, Kimberlee Gauvreau, Muhammad Muneeb, Laureen M. Sena, Steven D. Colan, Terry Saia, Mark W. Kieran Children’s Hospital, Boston.United States Congenital Heart DiseaseCongenit Heart Dis 2011; 6: 608-623DOI: 10.1111/j.1747-0803.2011.00574.x AbstractObjective: To determine the safety and efficacy of the chemotherapeutic agents vinblastine and methotrexate in the treatment of […]

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Systemic Sirolimus Therapy for Infants and Children With Pulmonary Vein Stenosis

Jay D. Patel, Michael Briones, Mansi Mandhani, Shannon Jones, Divya Suthar, Rosemary Gray, Joelle Pettus, Courtney McCraken, Amanda Thomas, Christopher J. Petit Emory University and Children’s Healthcare of AtlantaUnited States Journal of the American College of CardiologyJ Am Coll Cardiol 2021; 77: 2807-2818DOI: 10.1016/j.jacc.2021.04.013 AbstractBackground: Anatomic interventions for pulmonary vein stenosis (PVS) in infants and children have

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Acute Pulmonary Vasodilator Testing and Long-Term Clinical Course in Segmental Pulmonary Vascular Disease

Liezl Domingo, H. Sonali Magdo, Ronald W. Day University of Utah and Primary Children’s Hospital.United States Pediatric CardiologyPediatr Cardiol 2018; 39: 501-508DOI: 10.1007/s00246-017-1780-9 AbstractResults of acute pulmonary vasodilator testing (AVT) and the outcome of medical therapy have not been described in patients with segmental pulmonary vascular disease (SPVD). We sought to compare the pulmonary vasodilatory effects

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Systemic Sirolimus to Prevent In-Stent Stenosis in Pediatric Pulmonary Vein Stenosis

Ryan Callahan, Jesse J. Esch, Grace Wang, Christina M. Ireland, Kimberlee Gauvreau, Kathy J. Jenkins Boston Children’s Hospital and Harvard Medical School.United States Pediatric CardiologyPediatr Cardiol 2020; 41: 282-289DOI: 10.1007/s00246-019-02253-6 AbstractEvaluate the efficacy of systemic sirolimus (rapamycin) in preventing in-stent stenosis (ISS) in pediatric intraluminal pulmonary vein stenosis (PVS). Report the adverse events related to sirolimus

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Adjunct Targeted Biologic Inhibition Agents to Treat Aggressive Multivessel Intraluminal Pediatric Pulmonary Vein Stenosis

Ryan Callahan, Mark W. Kieran, Christopher W. Baird, Steven D. Colan, Kimberlee Gauvreau, Chistina M. Ireland, Audrey Marshall, Laureen M. Sena, Sara O. Vargas, Kathy J. Jenkins Boston Children’s Hospital and Harvard Medical School. Floating Hospital for Children at Tufts Medical Center. UMass Memorial Medical Center.United States Journal of PediatricsJ Pediatr 2018; 198: 29-35DOI: 10.1016/j.jpeds.2018.01.029 AbstractObjective: To

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Acute pulmonary edema caused by epoprostenol infusion in a child with scimitar syndrome and pulmonary hypertension

Christian von Schnakenburg, Matthias Peuster, Kambiz Norozi, Markus Roebl, Michael Maibohm, Armin Wessel, Armin Christoph Fink Georg-August-Universitaet Goettingen.Germany Pediatric Critical Care MedicinePediatr Crit Care Med 2003; 4: 111-114DOI: 10.1097/00130478-200301000-00023 AbstractIntroduction: Intravenous epoprostenol is frequently administered in adults and children for treatment of pulmonary hypertension. Although generally safe, pulmonary edema has been described in a few case reports

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