Article Type: Studies of Vascular Biology and Mechanism of Disease

A neonatal rat model of pulmonary vein stenosis

Debao Li, Lisheng Qiu, Haifa Hong, Hao Chen, Peibin Zhao, Yingying Xiao, Hao Zhang, Qi Sun, Lincai Ye Shanghai Children’s Medical Center and Shanghai Jiao Tong University. Second Affiliated Hospital and Yuying Children’s Hospital and Wenzhou Medical University. China Cell and BioscienceCell Biosci 2023; 13:DOI: 10.1186/s13578-023-01058-8 AbstractObjectives: Pulmonary vein stenosis (PVS), one of the most challenging clinical […]

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Targeted Rapamycin Delivery via Magnetic Nanoparticles to Address Stenosis in a 3D Bioprinted in Vitro Model of Pulmonary Veins

Liqun Ning, Stefano Zanella, Martin M. Tomov, Medhi Salar Amoli, Linqi Jin, Bouen Hwang, Maher Saadeh, Huang Chen, Sunder Neelakantan, Lakshmi Prasad Dasi, Reza Avazmohammadi, Morteza Mahmooudi, Holly D. Bauser-Heaton, Vahid Serpooshan Emory University School of Medicine, Children’s Healthcare of Atlanta and Georgia Institute of Technology. Cleveland State University. Texas A&M University. Michigan State University.United

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Mechanism of pulmonary vein stenosis in infants with normally connected veins

Iran M. Sadr, Puay E. Tan, Mark W. Kieran, Kathy J. Jenkins Children’s Hospital, Boston.United States American Journal of CardiologyAm J Cardiol 2000; 86: 577-579DOI: 10.1016/s0002-9149(00)01022-5 AbstractWe used microscopy, immunohistochemistry, and cell culture to identify the mechanism of restenosis in 4 infants with isolated pulmonary vein stenosis. Recurrent obstruction appears to be due to myofibroblastic proliferation

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Metakaryotic cells linked to pediatric pulmonary vein stenosis

Edward C. Kirkpatrick, Michael E. Mitchell, William G. Thilly, Pip Hidestrand, Aoy Tomita-Mitchell, Mats Hidestrand, Elena V. Gostjeva Children’s Hospital of Wisconsin and Medical College of Wisconsin. Massachusetts Institute of Technology. Eastern Maine Medical Center.United States Cardiovascular PathologyCardiovasc Pathol 2019; 39: 51-53DOI: 10.1016/j.carpath.2018.12.005 AbstractNo Abstract AvailableMethods: Pulmonary vein tissue from five patients with PVS was collected

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Paucicellular Fibrointimal Proliferation Characterizes Pediatric Pulmonary Vein Stenosis: Clinicopathologic Analysis of 213 Samples From 97 Patients

Alexandra E. Kovach, Philip M. Magcalas, Christina Ireland, Kerry McEnany, Andre M. Oliveira, Mark W. Kieran, Christopher W. Baird, Kathy Jenkins, MD, Sara O. Vargas Boston Children’s Hospital. Dana Farber Cancer Institute. Mayo Clinic.United States American Journal of Surgical PathologyAm J Surg Pathol 2017; 41: 1198-1204DOI: 10.1097/PAS.0000000000000892 AbstractPulmonary vein stenosis (PVS) is a luminal narrowing of

Paucicellular Fibrointimal Proliferation Characterizes Pediatric Pulmonary Vein Stenosis: Clinicopathologic Analysis of 213 Samples From 97 Patients Read More »

Lung Pathology in Pediatric Pulmonary Vein Stenosis

Jennifer E. Pogoriler, Thomas J. Kulik, Alicia M. Casey, Christopher W. Baird, Mary P. Mullen, Kathy J. Jenkins, Sara O. Vargas Boston Children’s Hospital and Harvard Medical School.United States Pediatric and Developmental PathologyPediatr Develop Pathol 2016; 19: 219-229DOI: 10.2350/15-07-1670-OA.1 AbstractPulmonary vein stenosis is a rare progressive narrowing of the extrapulmonary pulmonary veins, presenting predominantly in infancy

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Pulmonary vein stenosis and the pathophysiology of “upstream” pulmonary veins

Hideyuki Kato, Yaqin Yana Fu, Jiaquan Zhu, Shabana Aafaqi, Otto Rahkonen, Cameron Slorach, Alexandra Traister, Chung Ho Leung, David Chiasson, Luc Mertens, Lee Benson, Richard D. Weisel, Boris Hinz, Jason T. Maynes, John G. Coles, Christopher A. Caldarone Hospital for Sick Children and University of Toronto. Toronto General Hospital.Canada Journal of Thoracic and Cardiovascular SurgeryJ

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Pulmonary vein stenosis: expression of receptor tyrosine kinases by lesional cells

Wolfram F. J. Riedlinger, Amy L. Juraszek, Kathy J. Jenkins, Alan W. Nugent, Sowmya Balasubramanian, Monica L. Calicchio, Mark W. Kieran, Tucker Collins Children’s Hospital Boston and Harvard Medical School.United States Cardiovascular PathologyCardiovasc Pathol 2006; 15: 91-99DOI: 10.1016/j.carpath.2005.11.006 AbstractBackground: Primary pulmonary vein stenosis (PVS) is a progressive disorder of infants. Although catheter based intervention and chemotherapy are

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Losartan ameliorates “upstream” pulmonary vein vasculopathy in a piglet model of pulmonary vein stenosis

Jiaquan Zhu, HarukiIde, Yaqin Yana Fu, Anouk-Martine Teichert, Hideyuki Kato, Richard D. Weisel, Jason T. Maynes, John G. Coles, Christopher A. Caldarone The Hospital for Sick Children and University of Toronto. Toronto General Hospital.Canada Journal of Thoracic and Cardiovascular SurgeryJ Thorac Cardiovasc Surg 2014; 148: 2550-2557DOI: 10.1016/j.jtcvs.2014.07.050 AbstractObjectives: Pulmonary vein stenosis (PVS) is a relentless disease with

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Drug-eluting stents ameliorate pulmonary vein stenotic changes in pigs in vivo

Takeshi Furukawa, Masahiko Kishiro, Hideo Fukunaga, Masahiro Ohtsuki, Ken Takahashi, Katsumi Akimoto, Toshiaki Shimizu, Shiori Kawasaki, Toshio Kumasaka Juntendo University School of Medicine.Japan Pediatric CardiologyPediatr Cardiol 2010; 31: 773-779DOI: 10.1007/s00246-010-9695-8 AbstractThe outcome of stent implantation for pulmonary vein stenosis (PVS) in children remains poor. Several reports describe placing drug-eluting stents to treat PVS, but their effectiveness

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