Age Focus: Pediatric

Therapeutic Targets for Pediatric Pulmonary Vein Stenosis: Insights from Animal Models

Siqi She, Debao Li, Qi Sun, Lincai Ye Shanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Children’s Hospital of Fudan University and National Children’s Medical Center.China ChildrenChildren 2026; 13:DOI: 10.3390/children13050677 AbstractPulmonary vein stenosis (PVS) is a rare and devastating condition affecting infants and children, characterized by progressive intimal hyperplasia, myofibroblast proliferation, and

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Losartan attenuates upstream vasculopathy in a modified piglet model of pulmonary vein stenosis: contribution of the Hippo pathway

Wenhui Zeng, Siming Liu, Zhen Xu, Fangbao Ding, Ju Mei, Jiaquan Zhu Xinhua Hospital, Shanghai Jiaotong University School of Medicine.China Annals of Translational MedicineAnn Transl Med 2022; DOI: 10.21037/atm-22-2621 AbstractBackground: Diffuse pulmonary vein stenosis (PVS) is an intractable congenital heart disease for which the underlying mechanism remains unclear. In this study, we investigated the effect of losartan

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Transcatheter Interventional Options in Pulmonary Vein Stenosis: When to Stent?

Heidi Van Christopher J. Petit, Oliver M. Barry Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian Hospital Morgan Stanley Children’s HospitalUnited States Seminars in Thoracic and Cardiovascular Surgery Pediatric Cardiac Surgery AnnualSemin Thorac Cardiovasc Surg Pediatr Card Surg Ann 2026;DOI: 10.1053/j.pcsu.2026.02.007 AbstractPulmonary vein stenosis (PVS) is a rare and aggressive condition in infants and

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Pulmonary Vein Stenosis Medical Therapy: Current and on the Horizon

Mudit Gupta, David B. Frank Perelman School of Medicine at the University of Pennsylvania and Children’s Hospital of PhiladelphiaUnited States Seminars in Thoracic and Cardiovascular Surgery Pediatric Cardiac Surgery AnnualSemin Thorac Cardiovasc Surg Pediatr Card Surg Ann 2026;DOI: 10.1053/j.pcsu.2026.02.006 AbstractPulmonary vein stenosis (PVS) is a severe vascular obstructive lesion historically associated with poor survival. As outcomes

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Pulmonary arterial hypertension caused by compression of the left lower pulmonary vein in children

Li Chen, Cheng Wang, Jiachen Li, Lizhi Lv, Yongtao Wu, Gang Li, Guofeng Xing, Xiaoyong Jing, Zhimin Liu, Qiang Wang Beijing Anzhen Hospital and Capital Medical University.  Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.China Journal of Cardiothoracic SurgeryJ Cardiothorac Surg 2026;DOI: 10.1186/s13019-026-04085-x AbstractObjectives To investigate, through

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Characteristics and outcomes of preterm infants with pulmonary vein stenosis in the contemporary era: a PHIS database analysis

Mohamed F. Elsisy, Fred Z. Lam, Mark M. Naguib, Mary E. Dees, James C. Gay, George T. Nicholson Monroe Carell Jr. Children’s Hospital at Vanderbilt. United States Journal of PerinatologyJ Perinatol 2026; DOI: 10.1038/s41372-026-02703-z AbstractBackground: Pulmonary vein stenosis (PVS) is increasingly recognized in preterm infants, yet data regarding characteristics and outcomes remain limited.Methods: A review of hospitalizations from

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Surgical and Catheter-Based Intervention in Pediatric Pulmonary Vein Stenosis

Daiji Takajo, Paul J. Critser, Awais Ashfaq, Russel Hirsch Cincinnati Children’s Hospital Medical Center and University of Cincinnati. University of Texas Southwestern Medical Center. United States Pediatric CardiologyPediatr Cardiol 2026; DOI: 10.1007/s00246-026-04266-4 AbstractBackground: Pulmonary vein stenosis (PVS) is a rare but serious condition in children, often requiring surgical or catheter-based interventions. The initial optimal treatment strategy remains

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Pediatric Pulmonary Vein Stenosis and Treatment

Joice Prodigios, Stephanie El Omeiri, Marcus Meneses, Bethelhem Belachew, Hansel J. Otero, David M. Biko, Jordan B. Rapp Children’s Hospital of Philadelphia and Perelman School of Medicine at The University of Pennsylvania.United States Seminars in RoentenologySemin Roentenol 2025; DOI: 10.1053/j.ro.2025.09.006 AbstractPulmonary vein stenosis (PVS) is an uncommon but often progressive condition in children, associated with high

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Adams-Oliver syndrome with widespread CMTC and fatal pulmonary vascular disease

Ophelia Entsir Dadzie, Lidia Tyszczuk, Susan E. Holder, Fernanda Teixeira, Aikaterina Charakida, Julia Scarisbrick, Anthony Chu Hammersmith Hospital.United Kingdom Pediatric DermatologyPediatr Dermatol 2007; 24: 651-653DOI: 10.1111/j.1525-1470.2007.00556.x AbstractWe report a neonate with cutis marmorata telangiectatica congenita and clinical features of Adams-Oliver syndrome in association with severe pulmonary vascular disease. We provide an overview of cutis marmorata telangiectatica

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Abnormal Pericyte Recruitment as a Cause for Pulmonary Hypertension in Adams–Oliver Syndrome

Millan S. Patel, Glenn P. Taylor, Simi Bharya, Nouriya Al-Sanna’a, Ian Adatia, David Chitayat, M.E. Suzanne Lewis, Derek G. Human Hospital for Sick Children and University of Toronto. Children’s and Women’s Health Center of British Columbia and University of British Columbia. Canada American Journal of Medical Genetics Am J Med Genet 2004; 129A: 294-299DOI: 10.1002/ajmg.a.30221 AbstractAdams-Oliver

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